The effect of selective estrogen receptor modulator administration on the hypothalamic-pituitary-testicular axis in men with idiopathic oligozoospermia.
| Title | The effect of selective estrogen receptor modulator administration on the hypothalamic-pituitary-testicular axis in men with idiopathic oligozoospermia. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Tsourdi, E., Kourtis A., Farmakiotis D., Katsikis I., Salmas M., & Panidis D. |
| Journal | Fertil Steril |
| Volume | 91 |
| Issue | 4 Suppl |
| Pagination | 1427-30 |
| Date Published | 2009 Apr |
| ISSN | 1556-5653 |
| Keywords | Adult, Dose-Response Relationship, Drug, Follicle Stimulating Hormone, Humans, Hypothalamo-Hypophyseal System, Luteinizing Hormone, Male, Middle Aged, Oligospermia, Raloxifene, Selective Estrogen Receptor Modulators, Sperm Count, Sperm Motility, Tamoxifen, Testis, Testosterone, Toremifene |
| Abstract | This study evaluates, compares, and contrasts the effects of three selective estrogen receptor modulators (SERMs), namely, tamoxifen, toremifene, and raloxifene, on the hypothalamic-pituitary-testicular axis in 284 consecutive subfertile men with idiopathic oligozoospermia using three therapeutic protocols: [1] tamoxifen, 20 mg, once daily (n = 94); [2] toremifene, 60 mg, once daily (n = 99); and [3] raloxifene, 60 mg, once daily (n = 91). The antiestrogenic effects of SERMs at the hypothalamic level result in a statistically significant increase of gonadotropin levels, which is more marked for tamoxifen and toremifene compared with raloxifene. |
| DOI | 10.1016/j.fertnstert.2008.06.002 |
| Alternate Journal | Fertil. Steril. |
| PubMed ID | 18692782 |
