Twenty-four-hour intraocular pressure control with the travoprost/timolol maleate fixed combination compared with travoprost when both are dosed in the evening in primary open-angle glaucoma.
Title | Twenty-four-hour intraocular pressure control with the travoprost/timolol maleate fixed combination compared with travoprost when both are dosed in the evening in primary open-angle glaucoma. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Konstas, A. G. P., Mikropoulos D., Haidich A-B., Ntampos K. S., & Stewart W. C. |
Journal | Br J Ophthalmol |
Volume | 93 |
Issue | 4 |
Pagination | 481-5 |
Date Published | 2009 Apr |
ISSN | 1468-2079 |
Keywords | Adult, Aged, Antihypertensive Agents, Circadian Rhythm, Cloprostenol, Cross-Over Studies, Double-Blind Method, Drug Administration Schedule, Drug Combinations, Female, Glaucoma, Open-Angle, Humans, Intraocular Pressure, Male, Middle Aged, Timolol, Treatment Outcome |
Abstract | OBJECTIVE: To evaluate the 24 h efficacy and safety of the travoprost/timolol maleate fixed combination (TTFC) versus travoprost when both are dosed in the evening in primary open-angle glaucoma patients.METHODS: Prospective, double-masked, crossover, active-controlled, randomised 24 h comparison. After a 6 week medicine-free period, patients were randomised to either TTFC or travoprost for 8 weeks and were then switched to the opposite treatment for another 8 weeks. At the end of the washout and treatment periods, a 24 h pressure curve was performed.RESULTS: Thirty-two patients completed the study. The TTFC group demonstrated a lower absolute intraocular pressure level (2.4 mm Hg) for the 24 h curve and at all time points, compared with travoprost (p0.05).CONCLUSIONS: This study suggests that when both drugs are dosed in the evening the TTFC provides improved intraocular pressure reduction, compared with travoprost, over the 24 h curve and for each individual time point in primary open-angle glaucoma patients. |
DOI | 10.1136/bjo.2008.147322 |
Alternate Journal | Br J Ophthalmol |
PubMed ID | 19019932 |