Synthesis, characterization, toxicity, cytogenetic and in vivo antitumor studies of 1,1-dithiolate Cu(II) complexes with di-, tri-, tetra- amines and 1,3-thiazoles. Structure-activity correlation.
| Title | Synthesis, characterization, toxicity, cytogenetic and in vivo antitumor studies of 1,1-dithiolate Cu(II) complexes with di-, tri-, tetra- amines and 1,3-thiazoles. Structure-activity correlation. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Bolos, C. A., Chaviara A. T., Mourelatos D., Iakovidou Z., Mioglou E., Chrysogelou E., & Papageorgiou A. |
| Journal | Bioorg Med Chem |
| Volume | 17 |
| Issue | 8 |
| Pagination | 3142-51 |
| Date Published | 2009 Apr 15 |
| ISSN | 1464-3391 |
| Keywords | Amines, Animals, Antineoplastic Agents, Copper, Female, Humans, Leukemia P388, Ligands, Lymphocytes, Male, Mice, Mice, Inbred C57BL, Mice, Inbred DBA, Models, Molecular, Organometallic Compounds, Sister Chromatid Exchange, Spectrophotometry, Infrared, Structure-Activity Relationship, Sulfhydryl Compounds, Thiazoles |
| Abstract | A series of new mixed-ligand neutral copper(II) complexes of the general type [Cu(amine)(i-MNT)] and [Cu(tz)(i-MNT)] was prepared and characterized by elemental, spectroscopic methods, mu(eff), Lambda(mu) measurements and molecular modeling studies. The acute toxicity, the cytogenetic and the in vivo antitumor activity of the new complexes, is related to their chemical and physicochemical properties. Among the Cu(II) compounds tested the complex with 2-amino-5-methyl thiazole increases significantly the life span of leukemia P388 bearing mice in vivo. |
| DOI | 10.1016/j.bmc.2009.02.059 |
| Alternate Journal | Bioorg. Med. Chem. |
| PubMed ID | 19318255 |
