Kinetics and prognostic value of inflammatory-sensitive protein, IL-6, and white blood cell levels in patients undergoing coronary stent implantation.
Title | Kinetics and prognostic value of inflammatory-sensitive protein, IL-6, and white blood cell levels in patients undergoing coronary stent implantation. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Ziakas, A., Gavrilidis S., Giannoglou G., Souliou E., Koskinas K., Gemitzis K., Hatzimiltiadis S., Efthimiadis G., Paraskevaidis S., Hatzitolios A., Savopoulos C., & Parharidis G. |
Journal | Med Sci Monit |
Volume | 15 |
Issue | 4 |
Pagination | CR177-84 |
Date Published | 2009 Apr |
ISSN | 1643-3750 |
Keywords | Aged, Angioplasty, C-Reactive Protein, Coronary Disease, Female, Fibrinogen, Humans, Interleukin-6, Kinetics, Leukocyte Count, Male, Middle Aged, Prognosis, Prospective Studies, Stents |
Abstract | BACKGROUND: The levels of interleukin-6 (IL-6), white blood cells (WBCs), and some inflammatory-sensitive proteins (ISPs), such as fibrinogen (FIB) and C-reactive protein (CRP), have been related to coronary stent restenosis. The aim was to investigate the time course of the levels of IL-6, WBC, and several ISPs, i.e. FIB, CRP, cerruloplasmin (CER), haptoglobin (HPT), alpha-1 antitrypsin (A1AT), and alpha-1 acid glycoprotein (A1GP), after successful coronary stenting in patients with stable angina and to relate them to prognosis.MATERIAL/METHODS: FIB, CRP, IL-6, CER, HPT, A1AT, A1GP, and WBC levels were measured in 40 patients with stable angina before, and 6, 12, 24, 48, and 72 hours and 6 months after successful coronary stenting. The patients were followed up for 12 months.RESULTS: FIB levels increased significantly (p<0.05) 48 hours, CRP and WBC count 24 hours, CER, HPT, A1AT, and A1GP 72 hours, and IL-6 6 hours after stenting. All the levels remained unchanged in 20 control patients undergoing coronary angiography. During follow-up, stent restenosis occurred in 7 patients. Time-course and mean values of all the studied substances did not significantly differ in patients with or without restenosis (p>0.05).CONCLUSIONS: FIB, CRP, IL-6, CER, HPT, A1AT, A1GP, and WBC levels increase significantly after stenting, but they are not related to prognosis. |
Alternate Journal | Med. Sci. Monit. |
PubMed ID | 19333202 |