Carotid baroreceptor stimulation as a therapeutic target in hypertension and other cardiovascular conditions.
| Title | Carotid baroreceptor stimulation as a therapeutic target in hypertension and other cardiovascular conditions. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Doumas, M., Guo D., & Papademetriou V. |
| Journal | Expert Opin Ther Targets |
| Volume | 13 |
| Issue | 4 |
| Pagination | 413-25 |
| Date Published | 2009 Apr |
| ISSN | 1744-7631 |
| Keywords | Animals, Antihypertensive Agents, Baroreflex, Blood Pressure, Bradycardia, Cardiovascular Diseases, Carotid Sinus, Denervation, Dogs, Electric Stimulation Therapy, Electrodes, Implanted, Equipment Design, Homeostasis, Humans, Hypertension, Hypotension, Pressoreceptors, Pressure, Reflex, Abnormal, Solitary Nucleus, Vagus Nerve |
| Abstract | BACKGROUND: The role of the carotid baroreflex in blood pressure regulation has been known for a long time but its effects were thought to be short lived. Recent data indicate that stimulation of carotid baroreceptors may lower blood pressure not only for short periods of time, but also in the long run.OBJECTIVE/METHODS: Recent advances in technology permitted the development of a new device (Rheos) that addresses problems with older devices. Several questions remain to be addressed before Rheos can be used widely, and several potential clinical applications remain to be clarified. This review examines these issues and comprehensively describes this therapeutic approach.RESULTS/CONCLUSIONS: The carotid baroreceptor reflex is probably not completely in control of blood pressure. Baroreflexes are one of many control systems acting in concert. |
| DOI | 10.1517/14728220902780185 |
| Alternate Journal | Expert Opin. Ther. Targets |
| PubMed ID | 19335064 |
