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A novel noninvasive index for nonalcoholic steatohepatitis: a pilot study.

TitleA novel noninvasive index for nonalcoholic steatohepatitis: a pilot study.
Publication TypeJournal Article
Year of Publication2013
AuthorsPolyzos, S. A., Kountouras J., Slavakis A., Zafeiriadou E., Patsiaoura K., Katsiki E., Zavos C., Papatheodorou A., & Terpos E.
JournalBiomarkers
Volume18
Issue7
Pagination607-13
Date Published2013 Nov
ISSN1366-5804
KeywordsAspartate Aminotransferases, Biomarkers, Blood Sedimentation, Cross-Sectional Studies, Fatty Liver, Female, Greece, Homocysteine, Humans, Male, Middle Aged, Non-alcoholic Fatty Liver Disease, Pilot Projects, ROC Curve
Abstract

OBJECTIVE: The potential development of a noninvasive marker predicting nonalcoholic steatohepatitis (NASH).
METHODS: Thirty patients with biopsy-proven nonalcoholic fatty liver disease were evaluated by numerous anthropometric, clinical and biochemical parameters.
RESULTS: Serum glutamic oxaloacetic transaminase (SGOT; p = 0.027), log (erythrocyte sedimentation rate) (ESR; p = 0.034) and homocysteine (p = 0.041) were associated with NASH independently from gender, age and body mass index. When combined, the regression model provided R(2) = 0.563 (p = 0.001) and area under the ROC curve = 0.873 ± 0.066 (p < 0.001).
CONCLUSION: This noninvasive marker, named HSENSI (acronym of homocysteine, SGOT, ESR, Nonalcoholic Steatohepatitis Index), consists of three low cost, easily measurable parameters and may accurately predict NASH.
DOI10.3109/1354750X.2013.838305
Alternate JournalBiomarkers
PubMed ID24041134

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