24-hour intraocular pressure and blood pressure levels with latanoprost/timolol fixed combination versus timolol.
| Title | 24-hour intraocular pressure and blood pressure levels with latanoprost/timolol fixed combination versus timolol. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Konstas, A. G. P., Pikilidou M. I., Tsironi S., Mikropoulos D., Kozobolis V. P., Sarafidis P. A., Lasaridis A. N., Nelson L. A., & Stewart W. C. |
| Journal | Curr Eye Res |
| Volume | 34 |
| Issue | 5 |
| Pagination | 369-77 |
| Date Published | 2009 May |
| ISSN | 1460-2202 |
| Keywords | Aged, Blood Pressure, Circadian Rhythm, Cross-Over Studies, Drug Administration Schedule, Drug Combinations, Eye, Female, Glaucoma, Open-Angle, Humans, Intraocular Pressure, Male, Middle Aged, Ocular Hypertension, Prostaglandins F, Synthetic, Timolol |
| Abstract | PURPOSE: To evaluate 24-hr intraocular pressure (IOP) and blood pressure (BP) with timolol or latanoprost/timolol fixed combination (LTFC).METHODS: Patients with primary open-angle glaucoma or ocular hypertension with normal blood pressure were randomized to LTFC, dosed each evening, or timolol dosed twice daily in a cross-over design for 8 weeks and the opposite medicine for 8 weeks. IOP was measured at 02:00, 06:00, 10:00, 14:00, 18:00 and 22:00 hours in the sitting position with Goldmann applanation tonometry and BP monitoring every 30 min while awake and every hour while asleep at the end of each 8-week treatment period.RESULTS: Twenty-nine patients had a 24-hr baseline IOP of 26.3 +/- 2.5 mmHg, systolic BP (SBP) of 121.4 +/- 12.4 mmHg, diastolic BP (DBP) 72.9 +/- 7.1 mmHg, and ocular perfusion pressure (OPP) of 33.9 +/- 5.7 mmHg. No statistical differences were found between untreated and treated 24-hr SBP, DBP, mean BP (MBP), heart rate, or nocturnal BP dipping status with either medication. LTFC lowered IOP more at each timepoint compared to timolol (difference between treatments 2.7 mmHg, p = 0.0002).CONCLUSIONS: Neither timolol or evening-dosed LTFC reduced SBP, DBP, MBP, OPP, or increased nocturnal dipping. LTFC was more effective than timolol in decreasing IOP. |
| DOI | 10.1080/02713680902850075 |
| Alternate Journal | Curr. Eye Res. |
| PubMed ID | 19401880 |
