Aryl hydrocarbon receptor interacting protein (AIP) gene mutation analysis in children and adolescents with sporadic pituitary adenomas.
Title | Aryl hydrocarbon receptor interacting protein (AIP) gene mutation analysis in children and adolescents with sporadic pituitary adenomas. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Georgitsi, M., De Menis E., Cannavò S., Mäkinen M. J., Tuppurainen K., Pauletto P., Curtò L., Weil R. J., Paschke R., Zielinski G., Wasik A., Lubinski J., Vahteristo P., Karhu A., & Aaltonen L. A. |
Journal | Clin Endocrinol (Oxf) |
Volume | 69 |
Issue | 4 |
Pagination | 621-7 |
Date Published | 2008 Oct |
ISSN | 1365-2265 |
Keywords | Adenoma, Adolescent, Adult, Age of Onset, Amino Acid Sequence, Base Sequence, Child, Cohort Studies, DNA Mutational Analysis, Female, Germ-Line Mutation, Humans, Intracellular Signaling Peptides and Proteins, Male, Molecular Sequence Data, Pedigree, Pituitary Neoplasms, Young Adult |
Abstract | OBJECTIVE: Pituitary adenomas occur rarely in childhood and adolescence. Pituitary adenoma predisposition (PAP) has been recently associated with germline mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene. The aim of the study was to examine the proportion of germline AIP mutations in apparently sporadic paediatric pituitary adenomas. |
DOI | 10.1111/j.1365-2265.2008.03266.x |
Alternate Journal | Clin. Endocrinol. (Oxf) |
PubMed ID | 18410548 |