Can statins suppress the development of abdominal aortic aneurysms? A review of the current evidence.
| Title | Can statins suppress the development of abdominal aortic aneurysms? A review of the current evidence. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Saratzis, A., Kitas G. D., Saratzis N., & Melas N. |
| Journal | Angiology |
| Volume | 61 |
| Issue | 2 |
| Pagination | 137-44 |
| Date Published | 2010 Feb |
| ISSN | 1940-1574 |
| Keywords | Animals, Aortic Aneurysm, Abdominal, Blood Vessels, Cardiovascular Agents, Disease Progression, Heptanoic Acids, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Inflammation, Matrix Metalloproteinases, Models, Animal, Pyrroles, Risk Assessment, Simvastatin |
| Abstract | Statins possess several pleiotropic effects and have been shown in vitro and in vivo to inhibit the expression of inflammatory mediators and downregulate molecules involved in extracellular matrix (ECM) degradation. Recent observational studies in humans suggest that statins may have a role in abdominal aortic aneurysm (AAA) prevention or may even inhibit aneurysm expansion. In this review, we summarize the effects of statins on the vessel wall of aneurysmal aortas and currently available data concerning their inhibitory effects on aneurysm progression. |
| DOI | 10.1177/0003319709335514 |
| Alternate Journal | Angiology |
| PubMed ID | 19625274 |
