Effect of silodosin on detrusor overactivity in the male spontaneously hypertensive rat.
Title | Effect of silodosin on detrusor overactivity in the male spontaneously hypertensive rat. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Inoue, S., Saito M., Tsounapi P., Dimitriadis F., Ohmasa F., Kinoshita Y., Satoh K., & Takenaka A. |
Journal | BJU Int |
Volume | 110 |
Issue | 2 Pt 2 |
Pagination | E118-24 |
Date Published | 2012 Jul |
ISSN | 1464-410X |
Keywords | Administration, Oral, Adrenergic beta-1 Receptor Antagonists, Animals, Hypertension, Indoles, Male, Rats, Rats, Inbred SHR, Rats, Wistar, Receptors, Adrenergic, beta-1, RNA, Messenger, Urinary Bladder, Urinary Bladder, Overactive, Urination |
Abstract | UNLABELLED: Recently, several studies have suggested that detrusor overactivity (DO) is the result of bladder ischaemia. Hypertension could affect pelvic arterial blood flow, resulting in loss of smooth muscle in the bladder with resultant loss of bladder compliance. Spontaneously hypertensive rats are considered a valuable tool for exploring the pathogenesis of DO. Some reports indicate that α(1) adrenoceptor antagonists improve chronic ischaemia of the lower urinary tract in patients with LUTS, with concomitant improvement of their symptoms as well as improvement of DO through an increased bladder blood flow (BBF) in the rat with bladder outlet obstruction. However, the mechanism of improvement of silodosin on storage or irritative symptoms is not well investigated and is still unclear. Silodosin prevents hypertension-related DO in the SHR via several possible mechanisms. One possible mechanism of the efficacy of silodosin to the DO includes the improvement of the BBF. |
DOI | 10.1111/j.1464-410X.2011.10814.x |
Alternate Journal | BJU Int |
PubMed ID | 22146017 |