Spontaneous pancreatic undifferentiated pleomorphic sarcoma in a laboratory rat: A case report.
Title | Spontaneous pancreatic undifferentiated pleomorphic sarcoma in a laboratory rat: A case report. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Ypsilantis, P., Meditskou S., Lambropoulou M., Papamitsou T., & Simopoulos C. |
Journal | Animal Model Exp Med |
Volume | 2 |
Issue | 3 |
Pagination | 222-225 |
Date Published | 2019 Sep |
ISSN | 2576-2095 |
Abstract | We present a case of spontaneous undifferentiated/unclassified sarcoma, of a pleomorphic subtype formerly known as malignant fibrous histiocytoma (UPS/MFH), arising from the pancreas of a laboratory rat. The mass was excised after laparotomy from a 6-month-old female laboratory Wistar rat. It presented a giant multilobulated mass of irregular shape, which had arisen from the pancreas and occupied almost the entire peritoneal cavity. Histologically the tumor was characterized by a highly variable morphological pattern, with frequent transitions from storiform to pleomorphic areas. An extensive immunohistochemical examination revealed no specific lines of differentiation. Immunohistochemical positivity was observed only to MIB-1 (high Ki-67 proliferation index), vimentin and CD68 antibodies. The diagnosis was compatible with UPS/MFH. To the best of our knowledge, the present case is the first report of a spontaneous primary UPS/MFH arising from the pancreas of a laboratory rat. |
DOI | 10.1002/ame2.12078 |
Alternate Journal | Animal Model Exp Med |
PubMed ID | 31773099 |
PubMed Central ID | PMC6762044 |