Vitamin D supplementation and fracture risk: Evidence for a U-shaped effect.
Title | Vitamin D supplementation and fracture risk: Evidence for a U-shaped effect. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Anagnostis, P., Bosdou J. K., Kenanidis E., Potoupnis M., Tsiridis E., & Goulis D. G. |
Journal | Maturitas |
Volume | 141 |
Pagination | 63-70 |
Date Published | 2020 Nov |
ISSN | 1873-4111 |
Abstract | During the last decade, a cascade of evidence has questioned the anti-fracture efficacy of vitamin D supplementation. In general, vitamin D status, reflected by serum 25-hydroxy-vitamin D [25(OH)D] concentrations, seems to predict fracture risk and bone mineral density (BMD). Despite the well-documented detrimental effect of vitamin D deficiency on bones, vitamin D monotherapy does not seem to reduce the risk of fractures. On the other hand, high vitamin D doses, either at monthly (60,000-100,000 IU) or daily intervals (>4000 IU), appear to be harmful with regard to falls, fracture risk and BMD, especially for people without vitamin D deficiency and at low fracture risk. Therefore, a U-shaped effect of vitamin D on the musculoskeletal system may be supported by the current evidence. Vitamin D supplementation could be of value, at daily doses of at least 800 IU, co-supplemented with calcium (1000-1200 mg/day), in elderly populations, especially those with severe vitamin D deficiency [25(OH)D <25-30 nmol/L (<10-12 ng/mL)], although its anti-fracture and anti-fall efficacy is modest. Good compliance and at least 3-5 years of therapy are required. |
DOI | 10.1016/j.maturitas.2020.06.016 |
Alternate Journal | Maturitas |
PubMed ID | 33036705 |