The Impact of Obesity on the Association between Vitamin D Deficiency and Cardiovascular Disease.
Title | The Impact of Obesity on the Association between Vitamin D Deficiency and Cardiovascular Disease. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Paschou, S. A., Kosmopoulos M., Nikas I. P., Spartalis M., Kassi E., Goulis D. G., Lambrinoudaki I., & Siasos G. |
Journal | Nutrients |
Volume | 11 |
Issue | 10 |
Date Published | 2019 Oct 14 |
ISSN | 2072-6643 |
Keywords | Cardiovascular Diseases, Humans, Obesity, Vitamin D Deficiency |
Abstract | The aim of this article is to review the literature regarding the relationship between vitamin D deficiency and cardiovascular disease (CVD) and its modification in the presence of obesity. Despite the strong association between vitamin D status and cardiovascular outcomes, vitamin D supplementation trials in the general population have failed to decrease the incidence of cardiovascular events and mortality. A comprehensive study of the published literature and a comparison with experimental data lead to the conclusion that obesity, due to its high prevalence and strong association with both vitamin D deficiency and CVD, may act as a critical confounder, which is responsible for the different results on this association. Adoption of a vitamin D preventive supplementation strategy for CVD is unlikely to yield any benefit to the general population. However, it might be particularly useful in obese adults with increased risk for CVD. |
DOI | 10.3390/nu11102458 |
Alternate Journal | Nutrients |
PubMed ID | 31615154 |
PubMed Central ID | PMC6835874 |