Isolation of a novel embryonic stem cell cord blood-derived population with in vitro hematopoietic capacity in the presence of Wharton's jelly-derived mesenchymal stromal cells.
Title | Isolation of a novel embryonic stem cell cord blood-derived population with in vitro hematopoietic capacity in the presence of Wharton's jelly-derived mesenchymal stromal cells. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Gounari, E., Daniilidis A., Tsagias N., Michopoulou A., Kouzi K., & Koliakos G. |
Journal | Cytotherapy |
Volume | 21 |
Issue | 2 |
Pagination | 246-259 |
Date Published | 2019 02 |
ISSN | 1477-2566 |
Keywords | Adult Stem Cells, Antigens, CD34, Cell Cycle, Cell Differentiation, Cell Separation, Cells, Cultured, Coculture Techniques, Embryonic Stem Cells, Fetal Blood, Flow Cytometry, Hematopoiesis, Hematopoietic Stem Cell Transplantation, Humans, Mesenchymal Stem Cells, Wharton Jelly |
Abstract | BACKGROUND: Recent studies highlight the existence of a population of cord blood (CB)-derived stem cells that bare embryonic features (very small embryonic-like stem cells [VSELs]) as the most primitive CB-stem cell population. In the present study, we present for the first time a novel and high purity isolation method of VSELs with in vitro hematopoietic capacity in the presence of Wharton's jelly-derived mesenchymal stromal cells (WJ-MSCs). |
DOI | 10.1016/j.jcyt.2018.11.006 |
Alternate Journal | Cytotherapy |
PubMed ID | 30522805 |