Erythropoietin prevents hypoxia/ischemia-induced DNA fragmentation in an experimental model of perinatal asphyxia.
| Title | Erythropoietin prevents hypoxia/ischemia-induced DNA fragmentation in an experimental model of perinatal asphyxia. |
| Publication Type | Journal Article |
| Year of Publication | 2004 |
| Authors | Spandou, E., Soubasi V., Papoutsopoulou S., Karkavelas G., Simeonidou C., Kaiki-Astara A., & Guiba-Tziampiri O. |
| Journal | Neurosci Lett |
| Volume | 366 |
| Issue | 1 |
| Pagination | 24-8 |
| Date Published | 2004 Aug 05 |
| ISSN | 0304-3940 |
| Keywords | Animals, Animals, Newborn, Asphyxia Neonatorum, Brain, Disease Models, Animal, DNA Fragmentation, Erythropoietin, Female, Humans, Hypoxia-Ischemia, Brain, Infant, Newborn, Male, Neuroprotective Agents, Rats, Rats, Wistar, Reflex |
| Abstract | Erythropoietin (EPO) prevents neuronal damage following ischemic, metabolic and excitotoxic stress. Recent studies have shown that EPO plays a significant role in the developing brain. The present study investigates the effect of EPO administration on hypoxic-ischemic brain injury and the possibility that its neuroprotective action may be associated with anti-apoptotic activity. Seven-day-old rats were treated with EPO (2000 U/kg) and subjected to a modified Levine procedure. EPO administration before the hypoxic-ischemic insult significantly reduces the severity of brain damage and improved the short-term functional brain recovery. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling and DNA electrophoresis displayed no evidence of DNA fragmentation in EPO-treated animals. These results suggest that EPO might protect the neonatal rat brain by anti-apoptotic mechanisms. |
| DOI | 10.1016/j.neulet.2004.05.032 |
| Alternate Journal | Neurosci Lett |
| PubMed ID | 15265583 |
