Association of Notch and Hedgehog Pathway Activation With Prognosis in Early-stage Colorectal Cancer.
Title | Association of Notch and Hedgehog Pathway Activation With Prognosis in Early-stage Colorectal Cancer. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Rallis, G., Koletsa T., Saridaki Z., Manousou K., Koliou G-A., Kostopoulos I., Kotoula V., Makatsoris T., Kourea H. P., Raptou G., Chrisafi S., Samantas E., Papaparaskeva K., Pazarli E., Papakostas P., Kafiri G., Mauri D., Papoudou-Bai A., Christodoulou C., Petraki K., Dombros N., Pectasides D., & Fountzilas G. |
Journal | Anticancer Res |
Volume | 39 |
Issue | 4 |
Pagination | 2129-2138 |
Date Published | 2019 Apr |
ISSN | 1791-7530 |
Keywords | Adult, Aged, Aged, 80 and over, Colorectal Neoplasms, Disease-Free Survival, Female, Hedgehog Proteins, Humans, Jagged-1 Protein, Kaplan-Meier Estimate, Male, Middle Aged, Prognosis, Receptor, Notch2, Receptor, Notch3, Signal Transduction, Young Adult |
Abstract | BACKGROUND/AIM: Early-stage colorectal cancer (CRC) carries a wide range of survival probabilities. Novel biomarkers in this setting are eagerly awaited. Cancer stem cells (CSCs) are considered one of the reasons for treatment failure. This study sought to determine whether activation of pathways governing the function of CSC's could correlate with treatment outcomes. |
DOI | 10.21873/anticanres.13326 |
Alternate Journal | Anticancer Res |
PubMed ID | 30952759 |