Cyclin D1, EGFR, and Akt/mTOR pathway. Potential prognostic markers in localized laryngeal squamous cell carcinoma.
Title | Cyclin D1, EGFR, and Akt/mTOR pathway. Potential prognostic markers in localized laryngeal squamous cell carcinoma. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Dionysopoulos, D., Pavlakis K., Kotoula V., Fountzilas E., Markou K., Karasmanis I., Angouridakis N., Nikolaou A., Kalogeras K. T., & Fountzilas G. |
Journal | Strahlenther Onkol |
Volume | 189 |
Issue | 3 |
Pagination | 202-14 |
Date Published | 2013 Mar |
ISSN | 1439-099X |
Keywords | Adult, Aged, Aged, 80 and over, Biomarkers, Tumor, Carcinoma, Squamous Cell, Combined Modality Therapy, Cyclin D1, ErbB Receptors, Female, Humans, Laryngeal Neoplasms, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Staging, Prognosis, Retrospective Studies, RNA, Messenger, TOR Serine-Threonine Kinases |
Abstract | INTRODUCTION: EGFR (epidermal growth factor receptor), cyclin D1 and Akt/mTOR pathways are active in head and neck cancer. The aim of this study was to explore biomarker expression, their correlations with clinicopathological parameters and their prognostic utility in a cohort of patients with localized squamous laryngeal carcinoma. |
DOI | 10.1007/s00066-012-0275-0 |
Alternate Journal | Strahlenther Onkol |
PubMed ID | 23400686 |