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Secondary nocturnal enuresis related to central diabetes insipidus as an early manifestation of intracranial germinomatous germ cell tumors in a series of male youngsters.

TitleSecondary nocturnal enuresis related to central diabetes insipidus as an early manifestation of intracranial germinomatous germ cell tumors in a series of male youngsters.
Publication TypeJournal Article
Year of Publication2015
AuthorsPapaefthimiou, A., Kyrgios I., Kotanidou E. P., Maggana I., Mouzaki K., & Galli-Tsinopoulou A.
JournalAnn Endocrinol (Paris)
Volume76
Issue1
Pagination67-70
Date Published2015 Feb
ISSN2213-3941
KeywordsAdolescent, Body Height, Brain Neoplasms, Child, Combined Modality Therapy, Diabetes Insipidus, Neurogenic, Hormone Replacement Therapy, Humans, Magnetic Resonance Imaging, Male, Neoplasms, Germ Cell and Embryonal, Nocturnal Enuresis, Puberty, Delayed
Abstract

Nocturnal enuresis is a common symptom in children. It is usually attributed to benign causes and diagnostic evaluation is not carried out. We report three male young patients initially presenting with short stature and nocturnal enuresis, related to diabetes insipidus, caused by intracranial germinomatous germ cell tumors. In all three cases, water deprivation tests confirmed diabetes insipidus. Extensive endocrinological investigation also showed further hormone deficiencies. Magnetic resonance imaging of the brain revealed the presence of a central nervous system lesion and histology confirmed the final diagnosis. Surgery, radiation with or without chemotherapy was conducted and the patients were treated with hormone replacement therapies. The patients after a long follow-up were free of disease. We present these cases to alert clinicians to bear in mind that the presence of an intracranial germinomatous germ cell tumor should at least be considered in a child presenting with bed wetting, especially if additional symptoms and signs, including late onset puberty and growth delay or morning hypernatremia, may coexist.

DOI10.1016/j.ando.2014.11.001
Alternate JournalAnn Endocrinol (Paris)
PubMed ID25558016

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