HLA-DQB1*05 association with Hashimoto's thyroiditis in children of Northern Greek origin.
| Title | HLA-DQB1*05 association with Hashimoto's thyroiditis in children of Northern Greek origin. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Giza, S., Galli-Tsinopoulou A., Lazidou P., Trachana M., & Goulis D. |
| Journal | Indian Pediatr |
| Volume | 45 |
| Issue | 6 |
| Pagination | 493-6 |
| Date Published | 2008 Jun |
| ISSN | 0019-6061 |
| Keywords | Adolescent, Child, Female, Gene Frequency, Genetic Predisposition to Disease, Greece, Hashimoto Disease, HLA-DQ Antigens, HLA-DQ beta-Chains, HLA-DR Antigens, HLA-DRB1 Chains, Humans, Male, Polymorphism, Genetic, Puberty |
| Abstract | In order to investigate HLA-DRB1 and HLADQB1 gene polymorphisms in Northern Greek pediatric population with Hashimoto's thyroiditis (HT), we analyzed the distribution of these alleles in 17 patients and in 181 healthy subjects using polymerase chain reaction. No significant association was detected between HT and alleles analyzed. However, HLA-DQB1*05 was significantly increased in patients with age of diagnosis > 10 years (87.5%) compared to those with age of diagnosis |
| Alternate Journal | Indian Pediatr |
| PubMed ID | 18599937 |
