Insulin improves clinical status of patients with cystic-fibrosis-related diabetes mellitus.
Title | Insulin improves clinical status of patients with cystic-fibrosis-related diabetes mellitus. |
Publication Type | Journal Article |
Year of Publication | 2001 |
Authors | Nousia-Arvanitakis, S., Galli-Tsinopoulou A., & Karamouzis M. |
Journal | Acta Paediatr |
Volume | 90 |
Issue | 5 |
Pagination | 515-9 |
Date Published | 2001 May |
ISSN | 0803-5253 |
Keywords | Adolescent, Adult, Body Mass Index, Child, Cystic Fibrosis, Diabetes Mellitus, Female, Glucose Tolerance Test, Humans, Insulin, Male, Nutritional Physiological Phenomena, Prospective Studies, Respiratory Function Tests |
Abstract | UNLABELLED: Cystic-fibrosis-related diabetes mellitus is frequently underdiagnosed and associated with deterioration of overall clinical status. The purpose of this prospective study was to investigate the influence of insulin on nutrition, lung function and clinical status of cystic fibrosis patients. For a period of 5 y, and at 6-mo intervals, body mass index, forced expiratory volume in 1 sec, Shwachman score, intravenous glucose tolerance test and first-phase insulin response were determined in 30 cystic fibrosis patients (age range 10-35 y) with exocrine pancreatic insufficiency. During the study period, six patients (3M and 3F; age range 15-22 y) developed diabetes and required insulin therapy. The decrease of first-phase insulin response coincided with deterioration of nutritional and clinical status, which improved significantly 6 mo after the institution of insulin. |
Alternate Journal | Acta Paediatr |
PubMed ID | 11430710 |