Lung cancer associated with neurofibromatosis type I.
Title | Lung cancer associated with neurofibromatosis type I. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Oikonomou, A., Mikroulis D., Mintzopoulou P., Lukman L., & Prassopoulos P. |
Journal | Case Rep Radiol |
Volume | 2013 |
Pagination | 869793 |
Date Published | 2013 |
ISSN | 2090-6862 |
Abstract | Lung cancer associated with neurofibromatosis type I is considered very rare, and only a few case reports have been described in the literature. There is some evidence that a genetic linkage between neurofibromatosis and carcinogenesis in the lung may exist. We present a 42-year-old female, lifetime nonsmoker with a known history of neurofibromatosis type I, free of respiratory symptoms, who underwent a low-dose HRCT of the lungs to investigate any occult interstitial lung changes. A solitary ill-defined nodule of a ground-glass opacity was detected incidentally in the middle lobe with no associated lymphadenopathy or metastatic disease. Several thin-walled lung cysts were also seen in the lower lobes. Histological analysis of the nodule after middle lobectomy revealed well-differentiated adenocarcinoma. The patient did not receive systemic chemotherapy or radiotherapy. She was free of disease on 18-month followup. |
DOI | 10.1155/2013/869793 |
Alternate Journal | Case Rep Radiol |
PubMed ID | 23533906 |
PubMed Central ID | PMC3600287 |