Treatment of giant Bowen's disease with sequential use of photodynamic therapy and imiquimod cream.
| Title | Treatment of giant Bowen's disease with sequential use of photodynamic therapy and imiquimod cream. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Sotiriou, E., Lallas A., APALLA Z., & Ioannides D. |
| Journal | Photodermatol Photoimmunol Photomed |
| Volume | 27 |
| Issue | 3 |
| Pagination | 164-6 |
| Date Published | 2011 Jun |
| ISSN | 1600-0781 |
| Keywords | Administration, Topical, Aged, Aminoquinolines, Antineoplastic Agents, Bowen's Disease, Head and Neck Neoplasms, Humans, Imiquimod, Male, Photochemotherapy, Remission Induction, Skin Neoplasms |
| Abstract | We present a 79-year-old man with a 2-year history of Bowen's disease. The 10 × 10 plaque was located on the right frontotemporal area. The patient was treated with two photodynamic therapy (PDT) sessions, performed 1 week apart, followed by five times per week application of imiquimod 5% cream for 6 consecutive weeks. Complete clinical and histological response was achieved 3 months after treatment was completed. The patient remains recurrence free 12 months after treatment. Cosmetic outcome was evaluated as fair because of residual erythema. Long-term follow-up is mandatory for assessment of recurrences. Further studies are needed in order to confirm the improved outcome using the combination of PDT and imiquimod cream. |
| DOI | 10.1111/j.1600-0781.2011.00586.x |
| Alternate Journal | Photodermatol Photoimmunol Photomed |
| PubMed ID | 21535173 |
