Placental volume at 11-13 weeks' gestation in the prediction of birth weight percentile.
| Title | Placental volume at 11-13 weeks' gestation in the prediction of birth weight percentile. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Plasencia, W., Akolekar R., Dagklis T., Veduta A., & Nicolaides K. H. |
| Journal | Fetal Diagn Ther |
| Volume | 30 |
| Issue | 1 |
| Pagination | 23-8 |
| Date Published | 2011 |
| ISSN | 1421-9964 |
| Keywords | Adult, Birth Weight, Female, Humans, Imaging, Three-Dimensional, Infant, Newborn, Infant, Small for Gestational Age, Placenta, Pregnancy, Pregnancy Trimester, First, Pregnancy-Associated Plasma Protein-A, Ultrasonography, Prenatal |
| Abstract | OBJECTIVE: To determine the value of placental volume measured by 3D ultrasound at 11-13 weeks' gestation in combination with maternal characteristics and serum pregnancy-associated plasma protein-A (PAPP-A) in the prediction of small and large for gestational age (SGA and LGA) neonates.METHODS: Maternal serum PAPP-A and placental volume were measured at 11-13 weeks in 3,104 singleton pregnancies. Regression analysis was used to examine the contribution of maternal characteristics, placental volume and PAPP-A in the prediction of SGA and LGA neonates.RESULTS: There was a significant association between placental volume and PAPP-A (r = 0.268, p < 0.0001). Median placental volume and PAPP-A, expressed as multiples of the median (MoM) in appropriate for gestational age (AGA) neonates, were reduced in the SGA group (placental volume 0.88 MoM, vs. 1.00 MoM in AGA, p < 0.0001; PAPP-A 0.92 MoM vs. 1.00 MoM in AGA, p = 0.019) and increased in the LGA group (placental volume 1.09 MoM vs. 1.00 MoM in AGA, p < 0.0001; PAPP-A 1.15 MoM vs. 1.00 MoM in AGA, p = 0.015). Maternal characteristics with either placental volume or PAPP-A detected about 30% of the SGA or LGA neonates, at a false positive rate of 10%.CONCLUSION: Measurement of placental volume and serum PAPP-A can improve the prediction of SGA or LGA neonates provided by maternal characteristics alone. |
| DOI | 10.1159/000324318 |
| Alternate Journal | Fetal Diagn Ther |
| PubMed ID | 21701132 |
