Are multiple cryoprobes additive or synergistic in renal cryotherapy?
Title | Are multiple cryoprobes additive or synergistic in renal cryotherapy? |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Young, J. L., McCormick D. W., Kolla S. B., Sountoulides P. G., Kaufmann O. G., Ortiz-Vanderdys C. G., Huynh V. B., Kaplan A. G., Jain N. S., Pick D. L., Andrade L. A., Osann K. E., McDougall E. M., & Clayman R. V. |
Journal | Urology |
Volume | 79 |
Issue | 2 |
Pagination | 484.e1-6 |
Date Published | 2012 Feb |
ISSN | 1527-9995 |
Keywords | Animals, Cryosurgery, Equipment Design, Female, Kidney, Laparoscopy, Sus scrofa, Swine, Ultrasonography |
Abstract | OBJECTIVE: To investigate the relationship between multiple cryoprobes was investigated to determine whether they work in an additive or synergistic fashion in an in vivo animal model because 1.47 mm (17-gauge) cryoprobes have been introduced to the armamentarium for renal cryotherapy.METHODS: Laparoscopic-guided percutaneous cryoablation was performed in both renal poles of 3 pigs using 3 IceRod cryoprobes. These 12 cryolesions were compared with 12 cryolesions using a single IceRod cryoprobe. Each cycle consisted of two 10-minute freeze cycles separated by a 5-minute thaw. The iceball volume was measured using intraoperative ultrasonography. The kidneys were harvested, and cryolesion surface area was calculated. The lesions were fixed and excised to obtain a volume measurement. Statistical analysis was used to compare the single probe results multiplied by 3 to the multiple probe group for iceball volume, cryolesion surface area, and cryolesion volume.RESULTS: The iceball volume for the first freeze cycle for the single cryoprobe multiplied by 3 was 8.55 cm3 compared with 9.79 cm3 for the multiple cryoprobe group (P=.44) and 10.01 cm3 versus 16.58 cm3 for the second freeze (P=.03). The cryolesion volume for the single cryoprobe multiplied by 3 was 11.29 cm3 versus 14.75 cm3 for the multiple cyroprobe group (P=.06). The gross cryolesion surface area for the single cryoprobe multiplied by 3 was 13.14 cm2 versus 13.89 cm2 for the multiple probe group (P=.52).CONCLUSION: The cryolesion created by 3 simultaneously activated 1.47-mm probes appears to be larger than that of an additive effect. The lesions were significantly larger as measured by ultrasonography and nearly so (P=.06) as measured by the gross cryolesion volume. |
DOI | 10.1016/j.urology.2011.10.042 |
Alternate Journal | Urology |
PubMed ID | 22192230 |
PubMed Central ID | PMC4051421 |
Grant List | P30 CA062203 / CA / NCI NIH HHS / United States |