Dermoscopy and confocal microscopy of nested melanoma of the elderly: recognizing a newly defined entity.
| Title | Dermoscopy and confocal microscopy of nested melanoma of the elderly: recognizing a newly defined entity. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Longo, C., Zalaudek I., Piana S., Pellacani G., Lallas A., Reggiani C., & Argenziano G. |
| Journal | JAMA Dermatol |
| Volume | 149 |
| Issue | 8 |
| Pagination | 941-5 |
| Date Published | 2013 Aug |
| ISSN | 2168-6084 |
| Keywords | Age Factors, Aged, Dermoscopy, Diagnosis, Differential, Female, Humans, Male, Melanoma, Microscopy, Confocal, Middle Aged, Skin Neoplasms |
| Abstract | IMPORTANCE: Nested melanoma of the elderly is a newly identified histopathologic variant of superficial spreading melanoma, characterized by intraepidermal large nests. However, the clinical, dermoscopic, and confocal aspects have been depicted only partially.OBSERVATIONS: In our cases series, nested melanoma was a flat, irregularly shaped lesion with variably pigmented and irregularly distributed globules on dermoscopic examination. Confocal microscopy revealed the presence of a "clod" pattern made of large compact nests with variable atypia. These findings correlated well with histopathologic features.CONCLUSIONS AND RELEVANCE: Nested melanoma of the elderly should be included in the differential diagnosis when a flat pigmented lesion, showing dermoscopically an irregular globular pattern, is seen in a patient older than 60 years. |
| DOI | 10.1001/jamadermatol.2013.321 |
| Alternate Journal | JAMA Dermatol |
| PubMed ID | 23740161 |
