Adiponectin gene polymorphisms in obese Greek youth.
| Title | Adiponectin gene polymorphisms in obese Greek youth. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Panagopoulou, P., Stamna E., Tsolkas G., Galli-Tsinopoulou A., Pavlitou-Tsiontsi E., Nousia-Arvanitakis S., & Vavatsi-Christaki N. |
| Journal | J Pediatr Endocrinol Metab |
| Volume | 22 |
| Issue | 10 |
| Pagination | 955-9 |
| Date Published | 2009 Oct |
| ISSN | 0334-018X |
| Keywords | Adiponectin, Adolescent, Body Composition, Child, Child, Preschool, Female, Genotype, Greece, Haplotypes, Humans, Insulin Resistance, Male, Obesity, Polymorphism, Single Nucleotide |
| Abstract | We investigated single nucleotide polymorphisms 45T --> G and 276G --> T of the adiponectin gene in 48 obese Greek children and adolescents (3.58-16.25 years old) and examined their association with adiponectin levels and insulin resistance (IR), estimated with HOMA-IR, AUC(insulin) and WBISI. The polymorphisms were: 45T/G in 13/48 (27%) and 45G/G in 2 (4%) individuals; 276G/T in 21/41 (51%) and 276T/T in 3 (8%) individuals. Adiponectin in carriers of one or two G-alleles at position 45 was comparable to 45T/T (10.11 +/- 6.19 vs 8.03 +/- 4.96 microg/ml). Adiponectin in carriers of one or two T-alleles at position 276 was comparable to 276G/G (9.73 +/- 5.19 vs 7.77 +/- 5.65 microg/ml). SNP 45T --> G was not associated with IR. SNP276G --> T was associated with decreased risk for IR (OR = 3.05, 95% CI = 1.2384-11.13). In conclusion, SNPs 45T --> G and 276G --> T are common in obese young Greeks. SNP276G --> T might be protective against IR. |
| Alternate Journal | J. Pediatr. Endocrinol. Metab. |
| PubMed ID | 20020584 |
