Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial.
Title | Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Vamvakis, A., Gkaliagkousi E., Lazaridis A., Grammatikopoulou M. G., Triantafyllou A., Nikolaidou B., Koletsos N., Anyfanti P., Tzimos C., Zebekakis P., & Douma S. |
Journal | Nutrients |
Volume | 12 |
Issue | 5 |
Date Published | 2020 May 07 |
ISSN | 2072-6643 |
Abstract | Lifestyle modification is an important component of essential hypertension (EH) therapy. The aim of the Hypertension Intensive Nutrition Treatment (HINTreat) parallel, randomized controlled trial was to examine the effect of a 6-month intensive lifestyle treatment (ILT) (diet plus exercise with monthly visits) compared to the usual care. A total of 76 adults with stage 1 EH were randomized (38 in each group). Dietary analysis, anthropometry, physical activity, biochemical and urine profile, blood pressure (BP), asymmetric dimethylarginine (ADMA), central hemodynamics, β-stiffness index and carotid intima media-thickness were evaluated. The dietary inflammatory index (DII) was calculated for each participant from the intake of 29 nutrients/food components. At the end of the trial, participants in the ILT group reduced their 24h urinary Na excretion ( ≤ 0.001), daytime systolic BP ( ≤ 0.048) and mean carotid β-stiffness index ( ≤ 0.005) and ameliorated their lipidemic profile compared to the standard care. Univariate analysis for the total sample showed a strong association between DII and ADMA levels (β = 0.089, ≤ 0.01). ILT is effective in improving the inflammatory components of the diet and selected cardiometabolic parameters, including arterial stiffness. |
DOI | 10.3390/nu12051326 |
Alternate Journal | Nutrients |
PubMed ID | 32392715 |
PubMed Central ID | PMC7284619 |
Grant List | 91770 / / Supporting Research and Academic Practices of the 3rd Internal Medicine Department / |