Fungal colonization in the neonatal intensive care unit: risk factors, drug susceptibility, and association with invasive fungal infections.
Title | Fungal colonization in the neonatal intensive care unit: risk factors, drug susceptibility, and association with invasive fungal infections. |
Publication Type | Journal Article |
Year of Publication | 2007 |
Authors | Farmaki, E., Evdoridou J., Pouliou T., Bibashi E., Panagopoulou P., Filioti J., Benos A., Sofianou D., Kremenopoulos G., & Roilides E. |
Journal | Am J Perinatol |
Volume | 24 |
Issue | 2 |
Pagination | 127-35 |
Date Published | 2007 Feb |
ISSN | 0735-1631 |
Keywords | Candidiasis, Cesarean Section, Cross Infection, Female, Humans, Infant, Newborn, Intensive Care Units, Neonatal, Male, Mouth, Mycoses, Prospective Studies, Rectum, Risk Factors, Time Factors, Trachea |
Abstract | A prospective study was conducted to determine risk factors for fungal colonization, drug susceptibility, and association with invasive fungal infections (IFIs) in a neonatal unit. On admission and weekly thereafter, surveillance fungal cultures were taken from mouth, rectum, and trachea of neonates with expected stays of > 1 week. Fungal colonization was detected in 72 (12.1%) of 593 neonates during 12 months. CANDIDA ALBICANS was isolated from 42% of colonized neonates. Although early colonization (age 1.3 +/- 0.2 days) was found in 2.5% of the neonates, late colonization (age 17.6 +/- 1.4 days) was noted in 14.2% of neonates hospitalized for > 5 days. Neonates born vaginally were at higher risk for early colonization than those delivered after cesarean section ( P = 0.01). By multivariate logistic regression, very low birthweight was the only independent risk factor for late colonization. Ten IFIs (nine candidemias) were diagnosed, yielding a rate of 1.1%. These episodes occurred in 6.9% of colonized neonates, compared with 0.76% of noncolonized neonates ( P = 0.002). C. ALBICANS was susceptible to azoles, but some non- ALBICANS CANDIDA spp. exhibited decreased susceptibility to these drugs. |
DOI | 10.1055/s-2007-970078 |
Alternate Journal | Am J Perinatol |
PubMed ID | 17304423 |