Molecular networks in respiratory epithelium carcinomas.
| Title | Molecular networks in respiratory epithelium carcinomas. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Pallis, A. G., Karamouzis M. V., Konstantinopoulos P. A., & Papavassiliou A. G. |
| Journal | Cancer Lett |
| Volume | 295 |
| Issue | 1 |
| Pagination | 1-6 |
| Date Published | 2010 Sep 1 |
| ISSN | 1872-7980 |
| Keywords | Animals, Antineoplastic Agents, Cell Transformation, Neoplastic, Humans, Lung Neoplasms, Metabolic Networks and Pathways, Receptors, Cell Surface, Respiratory Mucosa, Respiratory Tract Neoplasms, Signal Transduction |
| Abstract | Current anti-cancer research is focused on cell surface receptors targeting, mainly epidermal growth factor receptor and vascular endothelial growth factor receptor, against which a few targeted agents are now available in clinical practice. Recent improvements of our understanding on the intracellular networks that participate in respiratory epithelium carcinogenesis have further elucidated the role of a variety of molecules that represent attractive targets for novel therapeutic strategies. The aim of this review is to explore the potential therapeutic opportunities of the manipulation of these pathways. |
| DOI | 10.1016/j.canlet.2010.03.014 |
| Alternate Journal | Cancer Lett. |
| PubMed ID | 20381956 |
