Brain natriuretic peptide and the athlete's heart: a pilot study.
| Title | Brain natriuretic peptide and the athlete's heart: a pilot study. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Pagourelias, E. D., Giannoglou G., Kouidi E., Efthimiadis G. K., Zorou P., Tziomalos K., Karagiannis A., Athyros V. G., Geleris P., & Mikhailidis D. P. |
| Journal | Int J Clin Pract |
| Volume | 64 |
| Issue | 4 |
| Pagination | 511-7 |
| Date Published | 2010 Mar |
| ISSN | 1742-1241 |
| Keywords | Adult, Biological Markers, Cardiomyopathy, Hypertrophic, Echocardiography, Humans, Male, Natriuretic Peptide, Brain, Pilot Projects, Sports, Young Adult |
| Abstract | BACKGROUND: The role of brain natriuretic peptide (BNP) in differentiating the athlete's heart from maladaptive cardiac hypertrophy is unclear.METHODS: To address this issue, an integrated M mode, two-dimensional B mode and Doppler echocardiographical study were performed and plasma BNP levels were measured in 25 strength athletes, 25 patients with established hypertrophic cardiomyopathy (HCM) and 25 healthy volunteers.RESULTS: Among athletes, BNP levels correlated negatively with the total training time (r = -0.79, p = 0.002) and positively with ejection fraction (r = 0.58, p = 0.049) and fractional shortening (r = 0.57, p = 0.049). A BNP cut-off value of 11.8 pg/ml had 88% specificity and 74% negative predictive value for the exclusion of HCM.CONCLUSIONS: Brain natriuretic peptide might be useful as a preparticipation screening test in athletes. |
| DOI | 10.1111/j.1742-1241.2009.02184.x |
| Alternate Journal | Int. J. Clin. Pract. |
| PubMed ID | 20456196 |
