The english version of the website is under development. Wherever text appears in Greek, it means it has not been translated yet.

Δημοσίευση

Delayed foreign-body reaction to absorbable implants in metacarpal fracture treatment.

TitleDelayed foreign-body reaction to absorbable implants in metacarpal fracture treatment.
Publication TypeJournal Article
Year of Publication2010
AuthorsGivissis, P. K., Stavridis S. I., Papagelopoulos P. J., Antonarakos P. D., & Christodoulou A. G.
JournalClin Orthop Relat Res
Volume468
Issue12
Pagination3377-83
Date Published2010 Dec
ISSN1528-1132
KeywordsAbsorbable Implants, Adolescent, Adult, Aged, Bone Plates, Bone Screws, Debridement, Device Removal, Dioxanes, Equipment Design, Female, Foreign-Body Reaction, Fracture Fixation, Internal, Fracture Healing, Fractures, Bone, Greece, Humans, Male, Metacarpal Bones, Middle Aged, Reoperation, Retrospective Studies, Time Factors, Treatment Outcome
Abstract

BACKGROUND: First-generation bioabsorbable implants have been associated with a high complication rate attributable to weak mechanical properties and rapid degradation. This has led to the development of stronger devices with improved durability. However, the modern implants have raised concerns about potential late-occurring adverse reactions.QUESTIONS/PURPOSES: This retrospective study addressed the following questions: Can absorbable implants consisting of trimethylene carbonate, L-lactide, and D,L-lactide provide adequate fixation for healing of a metacarpal fracture? Will these implants obviate a second removal operation? What complications can occur in the reaction to implant breakdown?PATIENTS AND METHODS: Twelve unstable, displaced, metacarpal fractures were studied in 10 consecutive patients (seven men, three women; mean age, 36.4 years; range, 18-75 years). The fractures were treated with absorbable plates and screws consisting of the aforementioned copolymers and designed to resorb in 2 to 4 years. Nine patients (10 fractures) were available for clinical and radiographic followups (mean, 45.7 months; range, 34-61 months).RESULTS: Fracture healing was uneventful in all cases. Four patients experienced a foreign-body reaction during the second postoperative year and required surgical débridement to remove implant remnants. Histologic examination confirmed the diagnosis of a foreign-body reaction. Two other patients reported a transient local swelling that subsided without treatment.CONCLUSIONS: Our results indicate these absorbable implants for metacarpal fractures achieved adequate bone healing but simply postponed the problem of foreign-body reactions. Patients treated with bioabsorbable implants should be advised of potential late complications and should be followed for at least 2 years, possibly longer.

DOI10.1007/s11999-010-1388-3
Alternate JournalClin. Orthop. Relat. Res.
PubMed ID20473595
PubMed Central IDPMC2974869

Contact

Secretariat of the School of Medicine
 

Connect

School of Medicine's presence in social networks
Follow Us or Connect with us.