Oral contraceptive pretreatment significantly reduces ongoing pregnancy likelihood in gonadotropin-releasing hormone antagonist cycles: an updated meta-analysis.
| Title | Oral contraceptive pretreatment significantly reduces ongoing pregnancy likelihood in gonadotropin-releasing hormone antagonist cycles: an updated meta-analysis. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Griesinger, G., Kolibianakis E. Michaelis, Venetis C., Diedrich K., & Tarlatzis B. |
| Journal | Fertil Steril |
| Volume | 94 |
| Issue | 6 |
| Pagination | 2382-4 |
| Date Published | 2010 Nov |
| ISSN | 1556-5653 |
| Keywords | Contraceptives, Oral, Drug Administration Schedule, Female, Fertility Agents, Female, Gonadotropin-Releasing Hormone, Hormone Antagonists, Humans, Likelihood Functions, Odds Ratio, Pregnancy, Pregnancy Rate, Randomized Controlled Trials as Topic |
| Abstract | Ongoing pregnancy rate (PR) per randomized woman was found to be significantly lower in patients with oral contraceptive (OC) pill pretreatment (relative risk: 0.80, 95% confidence interval [CI]: 0.66-0.97; rate difference: -5%, 95% CI: -10% to -1%; fixed effects model) after pooling data from six randomized controlled trials encompassing 1,343 patients. Duration of stimulation (weighted mean difference [WMD]: +1.33 days, 95% CI: +0.61-2.05) and gonadotropin consumption (WMD: +360 IUs, 95% CI: +158-563) were significantly increased after OC pretreatment, but there was no statistically significant gain in the number of cumulus-oocyte complexes (WMD: +0.6 cumulus-oocyte complexes, 95% CI: -0.08-1.25). |
| DOI | 10.1016/j.fertnstert.2010.04.025 |
| Alternate Journal | Fertil. Steril. |
| PubMed ID | 20537631 |
