Serum and cerebrospinal fluid levels of colistin in pediatric patients.
| Title | Serum and cerebrospinal fluid levels of colistin in pediatric patients. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Antachopoulos, C., Karvanen M., Iosifidis E., Jansson B., Plachouras D., Cars O., & Roilides E. |
| Journal | Antimicrob Agents Chemother |
| Volume | 54 |
| Issue | 9 |
| Pagination | 3985-7 |
| Date Published | 2010 Sep |
| ISSN | 1098-6596 |
| Keywords | Adolescent, Anti-Bacterial Agents, Child, Child, Preschool, Colistin, Female, Gram-Negative Bacterial Infections, Humans, Infant, Male, Treatment Outcome |
| Abstract | Using a liquid chromatography-tandem mass spectrometry method, the serum and cerebrospinal fluid (CSF) concentrations of colistin were determined in patients aged 1 months to 14 years receiving intravenous colistimethate sodium (60,000 to 225,000 IU/kg of body weight/day). Only in one of five courses studied (a 14-year-old receiving 225,000 IU/kg/day) did serum concentrations exceed the 2 microg/ml CLSI/EUCAST breakpoint defining susceptibility to colistin for Pseudomonas and Acinetobacter. CSF colistin concentrations were <0.2 microg/ml but increased in the presence of meningitis (approximately 0.5 microg/ml or 34 to 67% of serum levels). |
| DOI | 10.1128/AAC.01799-09 |
| Alternate Journal | Antimicrob. Agents Chemother. |
| PubMed ID | 20585114 |
| PubMed Central ID | PMC2935015 |
