Inflammatory markers in middle-aged obese subjects: does obstructive sleep apnea syndrome play a role?
Title | Inflammatory markers in middle-aged obese subjects: does obstructive sleep apnea syndrome play a role? |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Steiropoulos, P., Papanas N., Nena E., Antoniadou M., Serasli E., Papoti S., Hatzizisi O., Kyriazis G., Tzouvelekis A., Maltezos E., Tsara V., & Bouros D. |
Journal | Mediators Inflamm |
Volume | 2010 |
Pagination | 675320 |
Date Published | 2010 |
ISSN | 1466-1861 |
Keywords | Adult, Biological Markers, C-Reactive Protein, Female, Fibrinogen, Humans, Inflammation, Interleukin-6, Male, Middle Aged, Obesity, Polysomnography, Sleep Apnea, Obstructive, Tumor Necrosis Factor-alpha |
Abstract | BACKGROUND: Obstructive Sleep Apnea Syndrome (OSAS) is associated with inflammation, but obesity may be a confounding factor. Thus, the aim of this study was to explore differences in serum levels of inflammation markers between obese individuals with or without OSAS.METHODS: Healthy individuals (n = 61) from an outpatient obesity clinic were examined by polysomnography and blood analysis, for measurement of TNF-alpha, IL-6, CRP, and fibrinogen levels. According to Apnea-Hypopnea Index (AHI), participants were divided into two BMI-matched groups: controls (AHI < 15/h, n = 23) and OSAS patients (AHI > or = 15/h, n = 38).RESULTS: OSAS patients had significantly higher TNF-alpha levels (P < .001) while no other difference in the examined inflammation markers was recorded between groups. Overall, TNF-alpha levels were correlated with neck circumference (P < .001), AHI (P = .002), and Oxygen Desaturation Index (P = .002).CONCLUSIONS: Obese OSAS patients have elevated TNF-alpha levels compared to BMI-matched controls, suggesting a role of OSAS in promoting inflammation, possibly mediated by TNF-a. |
DOI | 10.1155/2010/675320 |
Alternate Journal | Mediators Inflamm. |
PubMed ID | 20628509 |
PubMed Central ID | PMC2902040 |