Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study.
| Title | Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Liu, Y., Paajanen T., Westman E., Wahlund L-O., Simmons A., Tunnard C., Sobow T., Proitsi P., Powell J., Mecocci P., Tsolaki M., Vellas B., Muehlboeck S., Evans A., Spenger C., Lovestone S., & Soininen H. |
| Corporate Authors | AddNeuroMed Consortium |
| Journal | J Alzheimers Dis |
| Volume | 21 |
| Issue | 3 |
| Pagination | 947-66 |
| Date Published | 2010 |
| ISSN | 1875-8908 |
| Keywords | Aged, Aged, 80 and over, Alleles, Alzheimer Disease, Amygdala, Apolipoprotein E4, Cerebral Cortex, Cognition Disorders, Female, Gene Frequency, Genotype, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Risk Factors, Sex Factors |
| Abstract | The apolipoprotein E (APOE) ε4 allele is a risk factor for Alzheimer's disease (AD), but its effect on brain volumes is controversial. We explored the effect of the ε4 allele on regional cortical thickness and volume measurements using an automated pipeline in 111 subjects with mild cognitive impairment (MCI), 115 AD patients, and 107 age-matched healthy controls. The clinical data were used as covariates in the thickness and volume comparisons. The ε4 carriers had significantly smaller volume than non-carriers in caudate (p=0.028) in controls; in amygdala and caudate in the MCI group (p |
| DOI | 10.3233/JAD-2010-100201 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 20693633 |
