Dissecting the stress activating signaling pathways in acute pancreatitis.
| Title | Dissecting the stress activating signaling pathways in acute pancreatitis. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Giakoustidis, A., Mudan S. S., & Giakoustidis D. |
| Journal | Hepatogastroenterology |
| Volume | 57 |
| Issue | 99-100 |
| Pagination | 653-6 |
| Date Published | 2010 May-Jun |
| ISSN | 0172-6390 |
| Keywords | Acute Disease, Humans, NF-kappa B, Pancreatitis, Reactive Oxygen Species, Signal Transduction, Toll-Like Receptor 4, Transcription Factor AP-1, Tumor Necrosis Factor-alpha |
| Abstract | BACKGROUND/AIMS: Acute pancreatitis is a severe and frequently a life-threatening disease which can lead to pancreatic necrosis, acute lung injury, SIRS and MODS. The pathophysiologic pattern of acute pancreatitis is being investigated, when guidelines for treatment are being modified often and novel therapeutic strategies have failed to show real benefit in clinical practice.METHODOLOGY: The present paper reviews the role of nuclear factors NF-kappaB and AP-1, TNFalpha, and TLR-4 in acute pancreatitis.CONCLUSION: Understanding the inflammatory mediators expression, regulation of apoptosis and dissecting the stress activating signaling pathways in acute pancreatitis, is of paramount importance in order to achieve in the near future adequate therapeutic interventions. |
| Alternate Journal | Hepatogastroenterology |
| PubMed ID | 20698244 |
