Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling.
Title | Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Palmesino, E., Rousso D. L., Kao T-J., Klar A., Laufer E., Uemura O., Okamoto H., Novitch B. G., & Kania A. |
Journal | PLoS Biol |
Volume | 8 |
Issue | 8 |
Pagination | e1000446 |
Date Published | 2010 |
ISSN | 1545-7885 |
Keywords | Axons, Cell Adhesion Molecules, Neuronal, Cell Movement, Extracellular Matrix Proteins, Extremities, Forkhead Transcription Factors, Gene Expression Regulation, Developmental, Growth Cones, Homeodomain Proteins, LIM-Homeodomain Proteins, Motor Neurons, Nerve Tissue Proteins, Repressor Proteins, Serine Endopeptidases, Signal Transduction, Spinal Cord, Transcription Factors |
Abstract | Topographic neuronal maps arise as a consequence of axon trajectory choice correlated with the localisation of neuronal soma, but the identity of the pathways coordinating these processes is unknown. We addressed this question in the context of the myotopic map formed by limb muscles innervated by spinal lateral motor column (LMC) motor axons where the Eph receptor signals specifying growth cone trajectory are restricted by Foxp1 and Lhx1 transcription factors. We show that the localisation of LMC neuron cell bodies can be dissociated from axon trajectory choice by either the loss or gain of function of the Reelin signalling pathway. The response of LMC motor neurons to Reelin is gated by Foxp1- and Lhx1-mediated regulation of expression of the critical Reelin signalling intermediate Dab1. Together, these observations point to identical transcription factors that control motor axon guidance and soma migration and reveal the molecular hierarchy of myotopic organisation. |
DOI | 10.1371/journal.pbio.1000446 |
Alternate Journal | PLoS Biol. |
PubMed ID | 20711475 |
PubMed Central ID | PMC2919418 |
Grant List | 5R01NS047510-04 / NS / NINDS NIH HHS / United States IG1-74068 / / Canadian Institutes of Health Research / Canada MOP-77556 / / Canadian Institutes of Health Research / Canada NS053976 / NS / NINDS NIH HHS / United States R01 NS047510 / NS / NINDS NIH HHS / United States R01 NS047510-04 / NS / NINDS NIH HHS / United States R01 NS072804 / NS / NINDS NIH HHS / United States T32NS07449 / NS / NINDS NIH HHS / United States |