APOE ε2 allele is associated with larger regional cortical thicknesses and volumes.
| Title | APOE ε2 allele is associated with larger regional cortical thicknesses and volumes. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Liu, Y., Paajanen T., Westman E., Zhang Y., Wahlund L-O., Simmons A., Tunnard C., Sobow T., Proitsi P., Powell J., Mecocci P., Tsolaki M., Vellas B., Muehlboeck S., Evans A., Spenger C., Lovestone S., & Soininen H. |
| Corporate Authors | AddNeuroMed Consortium |
| Journal | Dement Geriatr Cogn Disord |
| Volume | 30 |
| Issue | 3 |
| Pagination | 229-37 |
| Date Published | 2010 |
| ISSN | 1421-9824 |
| Keywords | Age of Onset, Aged, Alleles, Alzheimer Disease, Apolipoprotein E2, Brain, Cerebral Cortex, Cognition Disorders, Data Interpretation, Statistical, Female, Gene Frequency, Genotype, Heterozygote, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neuropsychological Tests |
| Abstract | BACKGROUND: The protective effect of the apolipoprotein E (APOE) ε2 allele against Alzheimer's disease (AD) is controversial.OBJECTIVE: Our purpose was to clarify if the ε2 allele affects regional cortical thicknesses and volumes.METHODS: Regional cortical thicknesses and volumes were measured with an automated pipeline in 109 subjects with mild cognitive impairment, 114 AD patients and 105 age-matched healthy controls.RESULTS: In the mild cognitive impairment group, the ε2 carriers had thicker regional cortices at the transverse temporal cortex and parahippocampal gyrus than the subjects with ε3/ε3, and a larger cerebral gray matter and smaller lateral ventricles than the ε3/ε3 and ε4 carriers. In the AD group, the ε2 carriers had significantly thicker entorhinal and transverse temporal cortices, a larger whole cerebral gray matter, and smaller lateral ventricles than the subjects with the ε3/ε3 genotype, and a significantly thicker entorhinal cortex and larger cerebral gray matter than ε4 carriers. No APOE2 effect was found in the control group.CONCLUSION: The APOE ε2 allele is associated with larger regional cortical thicknesses and volumes in mild cognitive impairment and AD. |
| DOI | 10.1159/000320136 |
| Alternate Journal | Dement Geriatr Cogn Disord |
| PubMed ID | 20847553 |
