Overall and event-free survival of childhood lymphoma in Greece: analysis of harmonized clinical data over a 24-year active registration period.
| Title | Overall and event-free survival of childhood lymphoma in Greece: analysis of harmonized clinical data over a 24-year active registration period. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Karalexi, M. A., Pourtsidis A., Panagopoulou P., Moschovi M., Polychronopoulou S., Kourti M., Hatzipantelis E., Stiakaki E., Dana H., Bouka P., Ntzani E. E., & Petridou E. Th |
| Corporate Authors | NARECHEM-ST collaborating group |
| Journal | Leuk Lymphoma |
| Volume | 62 |
| Issue | 9 |
| Pagination | 2107-2119 |
| Date Published | 2021 Sep |
| ISSN | 1029-2403 |
| Keywords | Aged, Disease-Free Survival, Greece, Hodgkin Disease, Humans, Lymphoma, Non-Hodgkin, Progression-Free Survival |
| Abstract | We assessed event-free (EFS) and overall (OS) survival in 676 incident cases of childhood Hodgkin (HL) and non-Hodgkin (NHL) lymphoma actively registered in Greece (1996-2019). HL-OS was 96% and NHL-OS 85%, whereas HL-EFS was 86% and NHL-EFS was 81%, notably similar to the respective OS rates (HL: 95%, NHL: 85%) in developed countries. For HL, older age at diagnosis, high maternal education and close proximity to treatment centers were linked to remarkably favorable outcomes. By contrast, stage IV patients showed worse OS and EFS. HL patients with low levels of hemoglobin were associated with worse EFS (hazard ratio: 2.81, 95% confidence intervals: 1.09-7.22). OS (76%) and EFS (73%) were poor among high-risk NHL patients and those with increased LDH (71%). The identified predictors of poor disease outcome point to the need for intensification of individualized treatments. Ongoing clinical cancer registration entailing clinical components could contribute to use of state-of-the-art treatments. |
| DOI | 10.1080/10428194.2021.1907376 |
| Alternate Journal | Leuk Lymphoma |
| PubMed ID | 34114936 |
