Hypofractionated accelerated CT-guided interstitial ¹⁹²Ir-HDR-Brachytherapy as re-irradiation in inoperable recurrent cervical lymphadenopathy from head and neck cancer.
| Title | Hypofractionated accelerated CT-guided interstitial ¹⁹²Ir-HDR-Brachytherapy as re-irradiation in inoperable recurrent cervical lymphadenopathy from head and neck cancer. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Tselis, N., Ratka M., Vogt H-G., Kolotas C., Baghi M., Baltas D., Fountzilas G., Georgoulias V., Ackermann H., & Zamboglou N. |
| Journal | Radiother Oncol |
| Volume | 98 |
| Issue | 1 |
| Pagination | 57-62 |
| Date Published | 2011 Jan |
| ISSN | 1879-0887 |
| Keywords | Adult, Aged, Aged, 80 and over, Brachytherapy, Female, Head and Neck Neoplasms, Humans, Iridium Radioisotopes, Lymphatic Metastasis, Male, Middle Aged, Neck, Neoplasm Recurrence, Local, Prognosis, Radiotherapy Dosage, Survival Rate, Tomography, X-Ray Computed |
| Abstract | BACKGROUND: Despite significant improvements in the treatment of head and neck cancer (HNC), lymph node recurrences remain a clinical challenge after primary radiotherapy. The value of interstitial (IRT) brachytherapy (BRT) for control of lymph node recurrence remains unclear. In order to clarify its role a retrospective review was undertaken on the value of computed tomography (CT)-guided IRT high-dose-rate (HDR)-BRT in isolated recurrent disease from HNC.PATIENTS AND METHODS: From 2000 to 2007, 74 patients were treated for inoperable recurrent cervical lymphadenopathy. All patients had previously been treated with radical radiotherapy or chemoradiation with or without surgery. The HDR-BRT delivered a median salvage dose of 30.0 Gy (range, 12.0-36.0 Gy) in twice-daily fractions of 2.0-5.0 Gy in 71 patients and of 30.0 Gy (range, 10.0-36.0 Gy) in once-daily fractions of 6.0-10.0 Gy in three patients.RESULTS: The overall and disease-free survival rates at one, two and three years were 42%, 19%, 6%, and 42%, 37% and 19%, respectively. The local control probability at one, two and three years was 67% at all three time points. Grade III-IV complications occurred in 13% of patients.CONCLUSIONS: In patients with inoperable recurrent neck disease from HNC, hypofractionated accelerated CT-guided IRT-HDR-BRT can play an important role in providing palliation and tumor control. |
| DOI | 10.1016/j.radonc.2010.10.025 |
| Alternate Journal | Radiother Oncol |
| PubMed ID | 21129799 |
