Oxygenated perfluorocarbons protect the intestine from the ischemia/reperfusion injury in rabbits.
| Title | Oxygenated perfluorocarbons protect the intestine from the ischemia/reperfusion injury in rabbits. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Ntinas, A., Vrochides D., Iliadis S., Papageorgiou G., Alvanou-Achparaki A., Papadimitriou D., Spiridis C., & Gerasimidis T. |
| Journal | Vasc Endovascular Surg |
| Volume | 45 |
| Issue | 5 |
| Pagination | 426-32 |
| Date Published | 2011 Jul |
| ISSN | 1938-9116 |
| Keywords | alpha-Glucosidases, Analysis of Variance, Animals, Biopsy, Creatine Kinase, Cytoprotection, Disease Models, Animal, Enterocytes, Fluorocarbons, Intestines, Linear Models, Microscopy, Electron, Oxygen, Protective Agents, Rabbits, Reperfusion Injury, Sucrase, Time Factors |
| Abstract | OBJECTIVE: To investigate whether intraluminal administration of oxygenated perfluorocarbons (PFCs) protects the enterocyte from acute ischemia-reperfusion (I/R) injury.MATERIALS AND METHODS: Twenty rabbits were divided in 4 groups: sham-operated controls (group A), acute I/R (group B), acute I/R plus infusion of oxygenated PFCs 30 minutes before ischemia (group C), and acute I/R plus infusion of oxygenated PFCs 30 minutes before reperfusion (group D). Serum creatine phosphokinase (CPK) and mucosal disaccharidase activity were examined. Intestinal biopsies were obtained for electron microscopy study.RESULTS: Group B CPK mean values are 3495.2 ± 157.35 and 4855 ± 350.21 U/L. Group C: 2674.6 ± 265.87 and 3231 ± 232.30. Group D: 2382.2 ± 102.90 and 3217.6 ± 185.61 at 120 and 180 minutes (P<.05). At 180 minutes, maltase and sucrose values were 33.63, 51.88, 8.45, and 19.91, and 17.99, 22.87, 6.62, and 14.24 µmol/min per g for groups A, B, C, and D, respectively (P<.05). Histopathology showed the least cellular deterioration in PFC groups.CONCLUSION: Oxygenated PFCs protect the enterocyte during bowel I/R. |
| DOI | 10.1177/1538574411402223 |
| Alternate Journal | Vasc Endovascular Surg |
| PubMed ID | 21571774 |
