Mediators involved in retinopathy of prematurity and emerging therapeutic targets.
Title | Mediators involved in retinopathy of prematurity and emerging therapeutic targets. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Mataftsi, A., Dimitrakos S. A., & Adams G. G. W. |
Journal | Early Hum Dev |
Volume | 87 |
Issue | 10 |
Pagination | 683-90 |
Date Published | 2011 Oct |
ISSN | 1872-6232 |
Keywords | Erythropoietin, Granulocyte Colony-Stimulating Factor, Humans, Infant, Newborn, Insulin-Like Growth Factor I, Oxidative Stress, Protein Isoforms, Retinopathy of Prematurity, Vascular Endothelial Growth Factor A |
Abstract | Retinopathy of prematurity (ROP) is a potentially blinding disease of premature infants and despite timely treatment some infants develop retinal detachment and sight loss. Current treatment utilises laser therapy which causes destruction of treated retinal tissue resulting in field loss. There is considerable research work ongoing on neovascular eye disease which is likely to result in antiangiogenic approaches that will arrest the development of ROP by specifically targeting the involved molecular mediators. Some of these new therapeutic interventions have entered clinical trials. This article reviews new information available on the molecular pathogenesis of ROP which may result in novel treatments for ROP; it does not discuss the well-known role of oxygen in the development of ROP. |
DOI | 10.1016/j.earlhumdev.2011.05.009 |
Alternate Journal | Early Hum. Dev. |
PubMed ID | 21700404 |