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Early vascular aging and the role of central blood pressure.

TitleEarly vascular aging and the role of central blood pressure.
Publication TypeJournal Article
Year of Publication2011
AuthorsKotsis, V., Stabouli S., Karafillis I., & Nilsson P.
JournalJ Hypertens
Volume29
Issue10
Pagination1847-53
Date Published2011 Oct
ISSN1473-5598
KeywordsAging, Aorta, Blood Pressure, Cardiovascular Diseases, Humans, Hypertension, Models, Cardiovascular, Risk Factors, Vascular Stiffness
Abstract

Vascular aging is described as a gradual process involving biochemical, enzymatic, and cellular changes of the vasculature and modification of the signals that modulate them. On the basis of this conception a new pathophysiological model for deeper understanding of cardiovascular risk and its treatment was introduced. The idea of early vascular aging, that is the acceleration of vascular aging seems to be a promising tool for clinical guidance in individuals at increased cardiovascular risk or a strong family history of early cardiovascular manifestations. Increased arterial stiffness, dilation of central elastic arteries, impaired endothelial function and vasodilatation are dominant aspects of this premature process.

DOI10.1097/HJH.0b013e32834a4d9f
Alternate JournalJ. Hypertens.
PubMed ID21799443

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