Early vascular aging and the role of central blood pressure.
Title | Early vascular aging and the role of central blood pressure. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Kotsis, V., Stabouli S., Karafillis I., & Nilsson P. |
Journal | J Hypertens |
Volume | 29 |
Issue | 10 |
Pagination | 1847-53 |
Date Published | 2011 Oct |
ISSN | 1473-5598 |
Keywords | Aging, Aorta, Blood Pressure, Cardiovascular Diseases, Humans, Hypertension, Models, Cardiovascular, Risk Factors, Vascular Stiffness |
Abstract | Vascular aging is described as a gradual process involving biochemical, enzymatic, and cellular changes of the vasculature and modification of the signals that modulate them. On the basis of this conception a new pathophysiological model for deeper understanding of cardiovascular risk and its treatment was introduced. The idea of early vascular aging, that is the acceleration of vascular aging seems to be a promising tool for clinical guidance in individuals at increased cardiovascular risk or a strong family history of early cardiovascular manifestations. Increased arterial stiffness, dilation of central elastic arteries, impaired endothelial function and vasodilatation are dominant aspects of this premature process. |
DOI | 10.1097/HJH.0b013e32834a4d9f |
Alternate Journal | J. Hypertens. |
PubMed ID | 21799443 |