Is earlier administration of human chorionic gonadotropin (hCG) associated with the probability of pregnancy in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone (GnRH) antagonists? A prospective randomize
Title | Is earlier administration of human chorionic gonadotropin (hCG) associated with the probability of pregnancy in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone (GnRH) antagonists? A prospective randomize |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Kyrou, D., Kolibianakis E. M., Fatemi H. M., Tarlatzis B. C., Tournaye H., & Devroey P. |
Journal | Fertil Steril |
Volume | 96 |
Issue | 5 |
Pagination | 1112-5 |
Date Published | 2011 Nov |
ISSN | 1556-5653 |
Keywords | Adult, Belgium, Chorionic Gonadotropin, Drug Administration Schedule, Drug Therapy, Combination, Female, Fertility Agents, Female, Fertilization in Vitro, Follicle Stimulating Hormone, Human, Gonadotropin-Releasing Hormone, Hormone Antagonists, Humans, Infertility, Ovulation Induction, Pilot Projects, Pregnancy, Pregnancy Rate, Prospective Studies, Recombinant Proteins, Sperm Injections, Intracytoplasmic, Time Factors, Treatment Outcome |
Abstract | OBJECTIVE: To evaluate the association of timing of hCG administration and probability of pregnancy in patients stimulated with recombinant FSH/GnRH antagonists for IVF.DESIGN: Prospective randomized controlled clinical trial.SETTING: Dutch-speaking Free University of Brussels.PATIENT(S): One hundred twenty patients, aged <40 years, treated by IVF or intracytoplasmic sperm injection.INTERVENTION(S): Ovarian stimulation was achieved using recombinant FSH starting on day 2 of the menstrual cycle at a fixed dose. To inhibit premature LH surge, daily GnRH antagonist was used from day 6 of stimulation. Triggering of final oocyte maturation was performed using 10,000 IU of hCG. Patients were randomized to receive hCG either as soon as three or more follicles of size ≥16 mm were present on ultrasonography (early-hCG group) or 1 day after the above criterion was met (late-hCG group).MAIN OUTCOME MEASURE(S): Ongoing pregnancy rate.RESULT(S): Significant differences were observed between the early-hCG and the late-hCG group regarding E(2) (1,388 ± 931 [mean ± SD] vs. 2,040 ± 1,231 pg/mL, respectively) and P (0.8 ± 0.3 vs. 1.1 ± 0.5 ng/mL, respectively) levels on the day of hCG administration and the number of metaphase II oocytes (9.2 ± 7.1 vs. 6.1 ± 4.9, respectively). No significant differences were observed between the early-hCG and the late-hCG group regarding positive hCG (46.2% vs. 50%, respectively) and ongoing pregnancy rates (34.6% vs. 40.7%, respectively).CONCLUSION(S): The current study provides evidence that earlier administration of hCG is not associated with the probability of pregnancy in cycles stimulated with recombinant FSH and GnRH antagonists. |
DOI | 10.1016/j.fertnstert.2011.08.029 |
Alternate Journal | Fertil. Steril. |
PubMed ID | 21924414 |