Invasive aspergillosis in children with acquired immunodeficiencies.
| Title | Invasive aspergillosis in children with acquired immunodeficiencies. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Tragiannidis, A., Roilides E., Walsh T. J., & Groll A. H. |
| Journal | Clin Infect Dis |
| Volume | 54 |
| Issue | 2 |
| Pagination | 258-67 |
| Date Published | 2012 Jan 15 |
| ISSN | 1537-6591 |
| Keywords | Adolescent, Antibiotic Prophylaxis, Antifungal Agents, Aspergillosis, Child, Child, Preschool, Female, Humans, Immunocompromised Host, Immunologic Deficiency Syndromes, Male, Risk Factors |
| Abstract | Invasive aspergillosis has emerged as an important cause of morbidity and mortality in immunocompromised children. It remains difficult to diagnose, and outcome depends on early diagnosis, appropriate treatment, and restoration of host defenses. Pediatric patients represent a unique population in their clinical presentation and epidemiology, particularly in respect to the utility of newer diagnostic tools and the pharmacokinetics of antifungal agents. This article reviews the presentation and epidemiology of invasive aspergillosis in children and adolescents with acquired immunodeficiencies and discusses the value of current diagnostic tools and the options for treatment and prevention in this population. |
| DOI | 10.1093/cid/cir786 |
| Alternate Journal | Clin. Infect. Dis. |
| PubMed ID | 22075793 |
