Ondasetron versus haloperidol for the treatment of postcardiotomy delirium: a prospective, randomized, double-blinded study.
Title | Ondasetron versus haloperidol for the treatment of postcardiotomy delirium: a prospective, randomized, double-blinded study. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Tagarakis, G. I., Voucharas C., Tsolaki F., Daskalopoulos M. E., Papaliagkas V., Parisis C., Gogaki E., Tsagalas I., Sataitidis I., Tsolaki M., & Tsilimingas N. B. |
Journal | J Cardiothorac Surg |
Volume | 7 |
Pagination | 25 |
Date Published | 2012 |
ISSN | 1749-8090 |
Keywords | Aged, Aged, 80 and over, Analysis of Variance, Cardiac Surgical Procedures, Delirium, Double-Blind Method, Female, Haloperidol, Humans, Male, Neuropsychological Tests, Ondansetron, Postoperative Complications, Prospective Studies |
Abstract | BACKGROUND: To investigate the controlling efficacy of ondasetron and haloperidol in regard to the postcardiotomy delirium.METHODS: We included in this prospective, randomized, double-blinded study 80 patients who developed delirium after heart surgery with the application of heart lung-machine. The patients were divided into two, equally-sized groups, which on detection of delirium received ondasetron 8 mg iv or haloperidol 5 mg iv respectively. The statistical analysis compared the baseline and demographic characteristics of the two groups (age, gender, comorbidities, years of education, type of surgery etc.).RESULTS: Both ondasetron and haloperidol had very good delirium controlling effects, without statistically significant differences. DISCUSSION-CONCLUSIONS: Ondasetron and haloperidol are efficient agents as far as the treatment of postcardiotomy delirium is concerned. As, in addition, ondasetron bares milder side-effects, we believe this could be the agent of choice in patients developing postcardiotomy delirium in the future. |
DOI | 10.1186/1749-8090-7-25 |
Alternate Journal | J Cardiothorac Surg |
PubMed ID | 22436170 |
PubMed Central ID | PMC3378452 |