Daptomycin in vitro activity against methicillin-resistant Staphylococcus aureus is enhanced by D-cycloserine in a mechanism associated with a decrease in cell surface charge.
| Title | Daptomycin in vitro activity against methicillin-resistant Staphylococcus aureus is enhanced by D-cycloserine in a mechanism associated with a decrease in cell surface charge. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Gasch, O., Pillai S., Dakos J., Miyakis S., Moellering R., & Eliopoulos G. |
| Journal | Antimicrob Agents Chemother |
| Date Published | 2013 Jun 24 |
| ISSN | 1098-6596 |
| Abstract | The killing activity of daptomycin against an isogenic pair of daptomycin susceptible and daptomycin non-susceptible (DNS) MRSA strains was enhanced by the addition of certain cell wall agents at 1xMIC concentrations. However, when high inocula of DNS were used, no significant killing was observed in our experiments. Cytochrome c binding assays revealed D-cycloserine as the only agent associated with a reduction in the cell surface charge of both strains, at the concentrations used. |
| DOI | 10.1128/AAC.00799-13 |
| Alternate Journal | Antimicrob. Agents Chemother. |
| PubMed ID | 23796933 |
| PubMed Central ID | PMC3754330 |
