Increased visfatin in hemodialysis patients is associated with decreased demands for recombinant human erythropoietin.
Title | Increased visfatin in hemodialysis patients is associated with decreased demands for recombinant human erythropoietin. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Eleftheriadis, T., Pissas G., Remoundou M., Antoniadi G., Liakopoulos V., & Stefanidis I. |
Journal | Ren Fail |
Volume | 35 |
Issue | 10 |
Pagination | 1399-403 |
Date Published | 2013 |
ISSN | 1525-6049 |
Keywords | Aged, Anemia, Case-Control Studies, Cytokines, Erythropoietin, Female, Healthy Volunteers, Humans, Insulin Resistance, Iron, Kidney Failure, Chronic, Male, Middle Aged, Nicotinamide Phosphoribosyltransferase, Recombinant Proteins, Renal Dialysis |
Abstract | BACKGROUND: Studies detected an association between visfatin and markers of iron metabolism in patients with insulin resistance. In this study, such a relation was evaluated in hemodialysis (HD) patients. Also relations between visfatin and hepcidin, demands for recombinant human erythropoietin (rHuEpo), inflammation, and situations characterized by insulin resistance were evaluated.METHODS: After a four-week washout period from iron treatment, 33 HD patients and 20 healthy volunteers enrolled in the study. Serum visfatin, hepcidin, and interleukin-6 (IL-6) were assessed by means of enzyme-linked immunosorbent assay. Hemoglobin, serum iron, ferritin, and transferrin saturation (TSAT) were also measured.RESULTS: Visfatin was markedly increased in HD patients. Visfatin levels did not differ between diabetics and non-diabetics. No relation was detected between visfatin and body mass index or IL-6 in HD patients. From the markers of iron metabolism, the hepcidin included, visfatin was related only to TSAT. A strong positive relation was revealed between visfatin and hemoglobin, whereas visfatin was inversely related to rHuEpo dose. Resistance to rHuEpo index was inversely and independently of TSAT related to visfatin.CONCLUSION: Visfatin is increased in HD patients and it is associated with decreased demands for rHuEpo. |
DOI | 10.3109/0886022X.2013.828268 |
Alternate Journal | Ren Fail |
PubMed ID | 23964827 |