Fungal DNA detected in blood samples of patients who received contaminated methylprednisolone injections reveals increased complexity of causative agents.
| Title | Fungal DNA detected in blood samples of patients who received contaminated methylprednisolone injections reveals increased complexity of causative agents. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Zhao, Y., Armeanu E., DiVerniero R., Lewis T. A., Dobson R. C., Kontoyiannis D. P., Roilides E., Walsh T. J., & Perlin D. S. |
| Journal | J Clin Microbiol |
| Volume | 52 |
| Issue | 6 |
| Pagination | 2212-5 |
| Date Published | 2014 Jun |
| ISSN | 1098-660X |
| Keywords | Adult, Blood, DNA, Fungal, Drug Contamination, Female, Fungemia, Fungi, Genetic Variation, Humans, Iatrogenic Disease, Injections, Intravenous, Male, Methylprednisolone, Middle Aged, Real-Time Polymerase Chain Reaction, Synovial Fluid |
| Abstract | Using Exserohilum rostratum-specific and panfungal real-time PCR, we studied 24 blood samples and 2 synovial fluid specimens from 20 patients with persistent or worsening pain following injections of contaminated methylprednisolone. Seven blood specimens from 6 patients were significantly positive for fungal DNA by panfungal PCR, with multiple fungal species identified. |
| DOI | 10.1128/JCM.00854-14 |
| Alternate Journal | J. Clin. Microbiol. |
| PubMed ID | 24719442 |
| PubMed Central ID | PMC4042738 |
