Non-Aspergillus fungal infections in chronic granulomatous disease.
Title | Non-Aspergillus fungal infections in chronic granulomatous disease. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Dotis, J., Pana Z. Dorothea, & Roilides E. |
Journal | Mycoses |
Volume | 56 |
Issue | 4 |
Pagination | 449-62 |
Date Published | 2013 Jul |
ISSN | 1439-0507 |
Keywords | Adolescent, Adult, Aged, Antifungal Agents, Child, Child, Preschool, Female, Fungi, Granulomatous Disease, Chronic, Humans, Infant, Lung, Male, Middle Aged, Mycoses, Young Adult |
Abstract | Chronic granulomatous disease (CGD) is a congenital immunodeficiency, characterised by significant infections due to an inability of phagocyte to kill catalase-positive organisms including certain fungi such as Aspergillus spp. Nevertheless, other more rare fungi can cause significant diseases. This report is a systematic review of all published cases of non-Aspergillus fungal infections in CGD patients. Analysis of 68 cases of non-Aspergillus fungal infections in 65 CGD patients (10 females) published in the English literature. The median age of CGD patients was 15.2 years (range 0.1-69), 60% of whom had the X-linked recessive defect. The most prevalent non-Aspergillus fungal infections were associated with Rhizopus spp. and Trichosporon spp. found in nine cases each (13.2%). The most commonly affected organs were the lungs in 69.9%. In 63.2% of cases first line antifungal treatment was monotherapy, with amphotericin B formulations being the most frequently used antifungal agents in 45.6% of cases. The overall mortality rate was 26.2%. Clinicians should take into account the occurrence of non-Aspergillus infections in this patient group, as well as the possibility of a changing epidemiology in fungal pathogens. Better awareness and knowledge of these pathogens can optimise antifungal treatment and improve outcome in CGD patients. |
DOI | 10.1111/myc.12049 |
Alternate Journal | Mycoses |
PubMed ID | 23369076 |